Cryptococcal Meningitis and Anti-virulence Therapeutic Strategies
نویسندگان
چکیده
منابع مشابه
Cryptococcal meningitis: epidemiology and therapeutic options
Cryptococcal meningitis causes morbidity and mortality worldwide. The burden of disease is greatest in middle- and low-income countries with a high incidence of human immunodeficiency virus (HIV) infection. Patients taking immunosuppressive drugs and some immunocompetent hosts are also at risk. Treatment of cryptococcal meningitis consists of three phases: induction, consolidation, and maintena...
متن کاملCryptococcal meningitis: clinical, diagnostic and therapeutic overviews.
Cryptococcal meningitis has emerged as a leading cause of infectious morbidity and mortality in patients with AIDS. Among the human immunodeficiency virus (HIV)-seropositive subjects, cryptococcal meningitis is the second most common cause of opportunistic neuro-infection. Current trends are changing due to the marked improvement of quality and length of life produced by highly active antiretro...
متن کاملCryptococcal Meningitis
Virulence probably plays a relatively small role in the outcome of this infection: the crucial factor is the immune status of the host. The most serious infections usually develop, in fact, in patients with defective cell-mediated immunity, for example those with AIDS, organ transplantation, reticuloendothelial malignancy, corticosteroid treatment and sarcoidosis, but not in subjects with neutr...
متن کاملClinical and Therapeutic Aspects of Cryptococcal Meningitis in West Africa
Cryptococcus meningitis is the most severe form of cryptococcal infections that infects the brain parenchyma and sub-arachnoid space. It often progresses to fatal disease states when it goes untreated. The clinical presentation and disease course of cryptococcal infection is partially marked by changes that occur as a result of certain medical conditions including, use of glucocorticoids or oth...
متن کاملCryptococcal meningitis
© 2004 Blackwell Publishing Ltd the second most common cause of death in HIV infection after tuberculosis (French et al. 2002). Moreover, despite the availability of highly active antiretroviral therapy (HAART), it continues to pose diffi cult management questions in the industrialized world. Questions remain for physicians regarding the optimal combination of antifungal agents, duration of tre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2019
ISSN: 1664-302X
DOI: 10.3389/fmicb.2019.00353